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- Indexed articles, last 90 days
- 95
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- Oct 1, 2026
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- Jul 6, 2026
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Number of US Patents per Small-Molecule Drug Has Tripled Since 1990, Delaying Generics (opens the original)
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For small-molecule drugs, the number of US pharmaceutical patents per drug has more than tripled from 1990 to 2019, driven by increases in nonprimary patents, according to research reported in JAMA. Whereas primary patents address active ingredients, nonprimary patents cover other characteristics, such as formulations, delivery devices, or methods of use, study researchers explained, adding, “Large patent portfolios tend to delay competition because generic manufacturers generally must either ch
Pembrolizumab and Nivolumb Have Similar Outcomes in Advanced, Untreated Melanoma (opens the original)
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Initial treatment with either pembrolizumab or nivolumab leads to similar outcomes for patients with advanced, unresectable, or metastatic melanoma, according to research published in JAMA Network Open. Monoclonal antibodies targeting PD-1 are “mainstays” of cancer therapy, with pembrolizumab and nivolumab being used the most often, “but their comparative effectiveness and safety have not been established in a prospective randomized clinical trial,” study researchers explained. The researchers e
Apixaban vs Warfarin Appears Less Risky for Advanced CKD With AFib (opens the original)
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Contemporary observational data suggest ischemic stroke risk is lower with anticoagulation vs nonuse, and specifically, apixaban vs warfarin in patients with atrial fibrillation (AFib) and stage 4-5 chronic kidney disease (CKD) who do not require dialysis. A retrospective cohort study incorporated a 3-group target trial emulation framework to evaluate the initiation of apixaban or warfarin versus no oral anticoagulant (OAC) therapy in stage 4-5 nondialysis CKD with AFib. Investigators culled dat
Help for Pain, Depression Has Not Increased in Chemo Recipients Despite Increased Screening - Oncology Nurse Advisor (opens the original)
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Although oncology practices report increased screening and management of pain and depression in patients receiving chemotherapy, the proportion of patients reporting that they received help for these conditions has not increased. These findings were published in JCO Oncology Practice. The Oncology Care Model (OCM), developed by the Centers for Medicare & Medicaid Services, was aimed at improving the screening and management of pain and depression in oncology. In this study, researchers studied p
Assessing Palliative Care Screening Tools for Patients With Cancer (opens the original)
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A total of 19 screening tools for assessing palliative care needs among patients with cancer were identified in a recent scoping review, but with variation in their applications. The findings of the review were reported in the journal BMJ Supportive & Palliative Care. “Given the substantial heterogeneity observed across screening tools in terms of domain coverage and clinical application, reliance on a single screening instrument may be insufficient to capture the full spectrum of palliative car
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