HeyJaredProfessor Paul Knoepfler, Ph.D.
- Indexed articles, last 90 days
- 8
- Latest publication
- Aug 2, 2026
- Outlet visibility, for The Niche
- Top 10M sites
- Earliest in this view
- Jul 5, 2026
Latest articles
Weekly reads: FDA warning, Capricor pub vs. AdCom, stem cells can count, hydra regeneration (opens the original)
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How well do FDA warning and untitled letters address what the agency sees as noncompliant activities by unproven stem cell clinics and supplier firms? One might think these letters work well given the implicit threat that not complying with them could lead to more severe action. For instance, the FDA can seek injunctions. Yet, that […] The post Weekly reads: FDA warning, Capricor pub vs. AdCom, stem cells can count, hydra regeneration appeared first on <a hr
More farce or tragedy? What’s ahead after RFK Jr.’s PCAC kangaroo meeting green lit risky peptides (opens the original)
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As I was watching the PCAC meetings late last week on popular so-called wellness or pop peptides, a neologism jumped to mind: kangaroo meeting. I almost felt like this PCAC meeting was a theatrical play. I can’t decide if it was more tragedy or farce. We watched as some conflicted panel members participated and voted […] The post More farce or tragedy? What’s ahead after RFK Jr.’s PCAC kangaroo meeting green lit risky peptides appe
Weekly reads: MYC phosphorylation, reverse protein aging, mitochondria don’t like space, that peptide committee (opens the original)
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Why am I interested in MYC phosphorylation? What is MYC? Long-time readers of The Niche probably remember that the MYC family is one of my primary interests. These proteins are essential for normal development (and stem cell function) as well as contributing to the formation of many tumors when overexpressed or mutated. MYC was also […] The post Weekly reads: MYC phosphorylation, reverse protein aging, mitochondria don’t like space, th
Potentially highly-conflicted PCAC meets this week on pop peptides, but no waivers (opens the original)
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So-called wellness peptides are even more in the spotlight this week as the pharmacy compounding advisory committee or PCAC launches a series of meetings to evaluate restoration of compounding of these unproven peptide drugs. This committee is supposed to take FDA staff guidance into consideration as it decides what to recommend to the agency. Typically […] The post Potentially highly-conflicted PCAC meets this week on pop peptides, but no waivers appeared first
Weekly reads: T cell stem cells, thymus as anti-aging organ, octopus ribosomes, longevity ethics (opens the original)
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When immunology researchers talk about “T cell stem cells” (or stem T cells or T memory stem cells), are they talking more generally about hematopoietic stem cells? No, because those have much broader potential. The most primitive stem cell for T cells can make all the various kinds of mature T cells. It seems like […] The post Weekly reads: T cell stem cells, thymus as anti-aging organ, octopus ribosomes, longevity ethics appeared first on
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