HeyJaredGround Truths
Facts, data and analytics about biomedical matters
- Indexed issues, all indexed history
- 34
- Latest publication
- Oct 11, 2026
- Audience
- 204K subscribers
- Earliest indexed
- Dec 14, 2025
Latest issues
A Tale of Two T Cells (opens the original)
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In the journal Immunity a paper with an obscure title was published on October 9th, 2026. It was entitled “Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK+ to GZMB+ Tem cells to health trajectories,” which I think is one of the worst titles I have ever seen for, ironically, one of the most important papers in the science of aging. I still don’t understand why authors and journal editors use or allow such arcane titles! In this edition of Gro…
Michael Lewis: The NIH “Murder Mystery,” DOGE, and Our Government Immune System (opens the original)
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Micheal Lewis is one of, if not the best storyteller of our era. You know and likely have read his books Moneyball, The Big Short, The Blind Side, Flash Boys, Liar’s Poker, and The Undoing Project, to name a few. He has long been one of my favorite authors. This was the first interview that Michael did on his new book, BLOCKERS, published on October 6th, streamed live on Substack Sept 29th. It’s his 21st book and 4 of the last 5 have been about the US government: The Fifth Risk (2019), Premoniti…
Loss of Cell Identity Drives Human Aging (opens the original)
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Two new papers, one published today in Nature by Vadim Gladyshev and colleagues at Harvard, and a recent one in Cell by Juan Carlos Izpisua Belmonte and his team at Altos Labs, have provided a new model for the biology of aging, and what might be done to reverse it. Until recently we accepted…
The Big Holes in Wearable Heart Rate Variability And Readiness Scores (opens the original)
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On September 9th, Apple announced it was revamping its Apple Watch Health Sensing System, rolling out a Readiness score (0 to 10), and increasing the frequency of heart rate variability (HRV) outputs 24-fold. This can be viewed as upping its competition with various other consumer wearable sensors. These “readiness scores” as a composite of multiple metrics, with heart rate variability (HRV) being front and center for most. The majority of Am…
The Coronary Artery Inflammation Controversy (opens the original)
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Why did a big clinical trial that tested an anti-inflammatory drug fail to reduce heart events? Why did another pivotal trial of lowering Lp(a) fail to reduce heart events? In this edition of Ground Truths I’ll offer some explanations and introduce some new and relevant information. In part, this is about relying on surrogate endpoints like increased blood levels of interleukin-6 or Lp(a), which have been generally regarded as an accurate reflection of heightened risk for coronary artery events.
Recurring subjects
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Audience
204K subscribers
Measured Oct 20, 2026
Source's subscribers, not the number who saw an individual piece.
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