HeyJaredUnNatural Selection
~ Evolution by Design: Synthesizing Cross-Industry Innovation ~–Curious about what innovation looks like in industries vastly different from yours? The UnNatural Selection Podcast applies ‘Survival of the Fittest’ to the world of business innovation.
- Indexed episodes, last 90 days
- 13
- Latest publication
- Sep 29, 2026
- Audience
- Checking…
- Earliest in this view
- Jul 7, 2026
Latest episodes
Unplugged Arcade / LEGO • Ecosystem Arbitrage (opens the original)
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Dan Winger spent 18 years at LEGO designing the future of play. Now he’s doing something counterintuitive: building a new category of games by looking backward. In this episode, Dan explains how he identified an overlooked niche in stagnant barroom gaming, designed around social behavior rather than technology, and turned an experimental product into a rapidly emerging business. We explore niche strategy, ecosystem customers, product-market fit, skill versus randomness, manufacturing bottlenecks
Mass Eye & Ear • Selective Senses (opens the original)
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What if some of medicine’s biggest opportunities lie not in inventing new treatments, but in questioning what we already accept as standard practice? Dr. Rishi Singh , Chair of Ophthalmology at Mass General Brigham and Professor at Harvard Medical School , joins Nic to explore the evolution of ophthalmology through AI, imaging, oculomics, precision medicine, and remote care. They examine how AI can democratize expertise, how the eye can serve as a window into systemic disease, and why longitudin
Illumina • Public-Private Synergy (opens the original)
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Research & Diagnostics: Illumina • Eric Green What happens when the architect of genomic innovation inside government moves into one of the industry's most important companies? Dr. Eric Green , Chief Medical Officer of Illumina and former NHGRI Director, reflects on the transition from government to industry—and what it reveals about how innovation actually scales. The conversation explores public-private risk sharing, commercialization, multi-omics, AI, end-to-end genomic workflows, and the oft
Putnam Associates • Decision Quality in Low-Friction Information Economies (opens the original)
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Management Consulting: Putnam Associates • Matt Riordan What happens when AI makes answers abundant, routine work cheap, and entire business models vulnerable to disruption? Matt Riordan , CEO of Putnam Associates , joins Nic to explore how AI is transforming management consulting – and what that transformation reveals about competition, innovation, and organizational survival. Matt explains why the scarcity is no longer information, but judgment; why domain expertise and context may become even
Rudy Tanzi • Stopping Alzheimer’s Before Symptoms Start (opens the original)
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Stop the Wildfire Early Can we stop Alzheimer’s before it starts? Dr. Rudy Tanzi – Harvard Medical School professor, Director of the McCance Center for Brain Health at Mass General Brigham , and one of the pioneers of Alzheimer’s genetics – joins UnNatural Selection to explore how decades of discovery are changing our approach to one of humanity’s most feared diseases. Tanzi explains why the field is moving from treating symptoms to early prediction, early detection, and ultimately prevention—an
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