HeyJaredUncertainty Principles
When what we don’t know is more important than what we do. Wrestling with conflict and controversy in science, medicine, health and nutrition.
- Indexed issues, last 90 days
- 6
- Latest publication
- Sep 23, 2026
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- Earliest in this view
- Jul 12, 2026
Latest issues
The Black Hole at the Galactic Core of Obesity and GLP-1 Drug Science (opens the original)
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The answers to today’s quiz may seem obvious. The questions may seem entirely rhetorical. Regrettably, they are not. If you let common sense be your guide, you’re likely to pick answers the experts wouldn't. Q. If you were going to study a disorder of excess fat accumulation, wouldn’t you be at least vaguely interested in how fat storage is regulated?Yes?No?Now let me rephrase that, in case it wasn’t abundantly clear.Q. Since obesity can be defined on first principles as the accumulati
Is Sugar Toxic? Can It Cause Cancer? CHD? Frailty? Dementia? (opens the original)
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Excess sugar consumption is implicated in multiple cancers through insulin resistance, chronic inflammation, and metabolic reprogramming…. This study provides causal evidence linking early-life sugar availability to adult cancer risk. Chen Zhu, Weilong Zhang, “Early-life sugar restriction causally reduces adult cancer incidence and slows biological aging,” PNAS, August 4, 2026“[S]ugar provides only calories, and in a country where obesity and its attendant diseases remain a pressing public healt
Lowering LDL: Surely, a “Heart-Healthy” Diet Is Worth the Effort. Isn’t it? (opens the original)
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Although there are undoubtedly persons who would choose to participate in a lifelong regimen of dietary change to achieve results of this magnitude, we suspect that some might not.William Taylor et al., “Cholesterol Reduction and Life Expectancy,” 1987When I think about preventive medicine and the efforts we might take to extend our lives, or at least our healthspans as the longevity gurus like to put it, the first question that comes to mind is: is it worth it? To know if it’s worth it, of cour
Blah Health Journalism: Meat, Sauerkraut and Politics Edition. (opens the original)
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Question of the day: Why do people eat fad diets? Before we get to our multiple choices, let’s define the term. These days, a reasonable definition of a fad diet is a dietary regimen that becomes popular by making claims of substantial benefits while employing unconventional eating rules that are inadequately supported by scientific evidence. The word fad, of course, also implies a passing fancy, as Merriam-Webster says, “a practice or interest followed for a time with exaggerated zeal.”Hence, a
Karl-Anthony Towns, Food Noise, and Why GLP-1 Drugs Quiet the Brain (opens the original)
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Don’t it always seem to go that you don’t know what you’ve got till it’s gone…Joni Mitchell, Big Yellow Taxi Before we get to Joni Mitchell, food noise and GLP-1 drugs, let’s talk about Karl-Anthony Towns, aka KAT. I’m a sucker for a sports redemption story, and Towns and the newly-minted NBA-champion Knicks, the franchise winning its first title since 1973, were as good as those stories get. But now I want to talk about KAT’s eating behavior in his teenage years, which is more the fodder of thi
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