HeyJaredTrial Files
Free monthly newsletter that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox.
- Indexed issues, last 90 days
- 3
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- Sep 21, 2026
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- Jul 27, 2026
Latest issues
Trial Files: Antibiotic Duration for Infective Endocarditis, Carbocisteine vs. Hypertonic Saline for Acute Respiratory Failure, and Finerenone in CKD due to Glomerular Disease (opens the original)
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Can antibiotic therapy for infective endocarditis be safely shortened?Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis (POET II)Henning Bundgaard et al. NEJM (August 2026)Bottom Line: This was an open-label, randomized trial with 508 adults with left-sided infective endocarditis caused by Staphylococcus aureus, Enterococcus faecalis, or streptococcal species who had received at least 2 to 4 weeks of antibiotics and met clinical stabilization criteria. Patien
Trial Files Throwback: Prednisone Duration for COPD Exacerbation, Fluid Choice in ICU, and SGLT2i in DM2 with CKD (opens the original)
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What is the evidence for 5 days of glucocorticoid therapy for COPD exacerbation?Short-term vs Conventional Glucocorticoid Therapy in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (REDUCE)Leuppi JD, et al. JAMA (June 2013) Bottom Line: This was a double-blind, randomized, noninferiority trial with 314 patients presenting to the emergency department with acute exacerbations of COPD. Patients were randomized in a 1:1 ratio to receive 40 mg of prednisone daily for either 5 or 14 days,
Trial Files: Cefazolin for MSSA Bacteremia, Fosfomycin vs Continued IV β-Lactams for Complicated UTIs, and the YEARS algorithm for PE in Cancer Patients (opens the original)
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Want more ways to stay up to date on the latest RCTs? Download our Trial Files Highlighter Chrome Extension: a tool that highlights keywords on Chrome websites and links them to summaries of relevant RCTs. DOWNLOAD HERECan Cefazolin be used for MSSA Bacteremia? Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia (SNAP)Lee T.C. et al. NEJM (June 2026) <st
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