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The Physiology of Scale

From molecules to society—the science and business of translating human physiology at scale.

Newsletter · By Brooks Leitner, MD, PhD · Official site

Indexed issues, last 90 days
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Aug 31, 2026
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Jul 8, 2026
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Latest issues

  1. Issue · Aug 31, 2026

    Health and Longevity Have Always Been About Human Performance (opens the original)

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    In my 2017 applications to MD/PhD Programs I wrote:”Exercise has always played a substantial role in my life, and I believe its role in humans’ capacity for strength and endurance, as well as its therapeutic/preventive role in health and disease, is not fully understood. The NIH Common Fund’s MoTrPAC (Molecular Transducers of Physical Activity in Humans) shares this belief.”At the time, the MoTrPAC consortium was one of the largest national initiatives where funding and serious attention was bei

  2. Issue · Jul 8, 2026

    Why Would an MD-PhD Start a Company? (opens the original)

    Excerpt · Neutral tone

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    I heard some version of this question in nearly every conversation I had with investors while raising our pre-seed round. Happens with numerous clinicians, trainees, and scientists I speak with regularly as well.Usually it came right after the second most common question: what’s your specialty. Right before the third: why didn’t you do a residency after all that schooling?I’ve never had a crisp one-line answer, so I figured I’d write out the long one. It also doubles as a decent update on what I

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