HeyJaredStayCurious Metabolism
We will cultivate nuance and curiosity for all things metabolism. Make Metabolic Health Mainstream!
- Indexed issues, last 90 days
- 18
- Latest publication
- Sep 29, 2026
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- Aug 27, 2026
Latest issues
Your GLP-1 Might Be Turning “ON” Hunger Neurons (opens the original)
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This might be one of the strangest findings on GLP-1 weight-loss drugs I’ve come across this year.Researchers were studying neurons in the brain that are known to drive hunger. So, you’d expect drugs like semaglutide (Ozempic) to decrease the activity of these cells.Instead, they found the opposite. GLP-1 receptor agonists activated these hunger neurons.You read that right: a drug famous for reducing appetite appeared to switch on the very neurons that drive hunger. Bizarre. Completely paradoxic
Why You Can't Focus (opens the original)
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Have you ever had one of those days when you just can’t seem to focus?Maybe you didn’t sleep particularly well the night before. You sit down to write, read, build a presentation, or tackle an important project, and your mind immediately starts wandering.You check your phone. Scroll Instagram. Open YouTube. Click from one video to the next. You realize you can’t even stay focused on a single video for more than a few minutes before feeling the urge to switch to something else. You’re frustrated
Do You Ever Feel Like Your Doctor Hates You? (opens the original)
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There’s one phrase we learned in medical school that I absolutely hate: “If you hear hoofbeats, think horses, not zebras.”The idea is simple: the most common explanation is usually the correct diagnosis.That works great if you’re a horse. But if you’re a zebra, it sucks.Because when you don’t fit the usual pattern, you can get dismissed or misdiagnosed. And if you’re misdiagnosed, you can get mistreated.Unfortunately, I have a knack for being a zebra.<div class="captioned-image-contai
A Masterclass on Building Stronger Bones (opens the original)
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Here’s a not-so-fun fact: I used to have osteoporosis.Now, if you know even a little medicine, you might be skeptical. I’m a 30-year-old man who generally reports being healthy. So, the idea that I had osteoporosis sounds extreme.I was diagnosed around age 20 after an unusual series of events. What made the situation so strange is that I had never had any bone problems as a child. My first fracture occurred when I was 18 years old while training for the Boston Marathon. In fact, I was the younge
Rejuvenate Your Body's Anti-Cancer Defenses (opens the original)
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Somewhere in your body right now, a cell has started down the path toward cancer, and your immune system is finding it and shutting it down before it can ever become a tumor. The problem is that defense system declines as you age. This is, in fact, one of the primary reasons cancer rates increase with age. Not just because you accumulate genetic mutations, but because precancerous cells can escape your body’s natural defenses. But where does this process start to go wrong? One of the immune syst
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