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- Indexed issues, last 90 days
- 15
- Latest publication
- Sep 24, 2026
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- Earliest in this view
- Aug 20, 2026
Latest issues
Q&A 190: gababentinoids and dementia in MS (opens the original)
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QuestionI am a chronic user of Gabapentin, having taken it for eight years. I was first prescribed it for the shingles I had post-treatment with Alemtuzumab and found that it benefited me regarding my nerve pain due to the sheer number of lesions on my spinal cord. Since then, I have found that a daily dose of 700 mg, split into 300 mg and 400 mg, is the ideal maintenance dose. I am not aware of experiencing any side effects and was happy taking it knowing that, unlike, say, amitriptyline, it is
Q&A 189 - melanoma and HPV infection on siponimod; what should I do? (opens the original)
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QuestionI moved from beta interferon to siponimod in November 2024. I am 57, and I had my first relapse in 1997 (diagnosed c.2002). I haven’t had a relapse for at least 12 years but definitely have smouldering MS, as my mobility issues are progressing and I am on the cusp of being wheelchair bound. (I can take a few steps and pivot transfer, but it’s all getting very difficult)Being on siponimod, I had my annual mole check, and unfortunately a mole on my left thigh has come back as cancerous, a
Q&A 188 - motor MS relapses you are not aware of are more common than you expect (opens the original)
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QuestionIn May 2025, I received my last infusion of ocrelizumab (Ocrevus). I stopped treatment because I developed an immune deficiency.In May 2026, I had a follow-up brain MRI. The report stated:MRI brain, May 2026:There is a new punctate white matter lesion infratentorially at the level of the pons.The periventricular white matter abnormalities and the punctate deep white matter abnormalities in the left parietal and right frontal regions are unchanged. No diffusion restriction. No evidence of
Is EBV reactivation the trigger driving MS relapses? (opens the original)
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About ten people have contacted me in the past week to comment on this paper.King et al. EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse. Nat Med 2026 Sep 16. Online ahead of print.<d
Q&A 187: Journal Club (opens the original)
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QuestionDr G: Would you also please consider sharing your thoughts on this recent study, which found no significant differences in endpoints between “low, moderate and high efficacy” MS drugs? Thank you!<source type="image/webp" /
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