HeyJaredMaria Gutschi
Offscript Pharmacist. Off label analysis from a pharmacist who reads the fine print. Independent researcher. Independent thinker. Wife, mother, grandmother,
- Indexed issues, last 90 days
- 8
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- Sep 5, 2026
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- Jul 6, 2026
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The Wang study on LNPs and cancer: and the questions it leaves unanswered (opens the original)
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A rather heated exchange over a new mouse study reporting that an mRNA-vaccine-type lipid nanoparticle increased metastatic burden. Jeffrey Morris called the paper a “potential mechanistic hypothesis.” JikkyLeaks responded that the investigators had actually produced the effect experimentally.<div class="ima
Call2Halt19: The Questions Health Canada Still Has Not Answered (opens the original)
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<img alt="" class="sizing-normal" height="553" src="https://substackcdn.com/image/fetch/$s_!_BbQ!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2caeb63f-fd74-4aa4-8ea5-7cf33a786cb9_1710x649.png"
Exosomes, Schmectasomes: The Hidden Second Life of mRNA-LNPs (opens the original)
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Exosomes, schmectasomes. It is time I talked about exosomes. I revisited the Onpattro (patisiran) data and was struck by how much research into Onpattro’s regulatory authorization helps us understand mRNA technology and mRNA platform pharmacology. Skip to the Summary for the TL;DR version. Note: I use exosomes and extracellular vesicles interchangeably. Sorry. Technically, exosomes are a subtype of extracellular vesicle defined by their endosomal origin. Since plasma-isolation methods cannot pro
Always Early (opens the original)
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<img alt="" class="sizing-normal" height="1122" src="https://substackcdn.com/image/fetch/$s_!ynbh!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F277fbca0-fcf7-4c80-9f7f-79a973f815cf_1402x1122.p
Four Questions About mRNA-LNP "Vaccines" That Still Need Answers (opens the original)
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IntroductionA few weeks ago, Acta Pharmaceutica Sinica B published a paper I co-authored with Falko Seger and Stephanie Seneff: Lipid nanoparticles as active biointerfaces: From membrane interaction to systemic dysregulation.What we argue is straightforward: the lipid nanoparticles used in mRNA COVID vaccines are not inert delivery “bubbles.” As I keep emphasizing the LNPs are supramolecular assemblies that actively integrate into cellular membranes, disrupt the phosphatidylinositol cycle (the m
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