HeyJaredLongevity Lifehacks
Exploring the current research on healthspan and longevity with an eye towards practical solutions and an appreciation of out-of-the-box thinking.
- Indexed issues, last 90 days
- 9
- Latest publication
- Sep 28, 2026
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- Jul 7, 2026
Latest issues
Alzheimer’s Lifehacks: The Map (opens the original)
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Hi everyone - Longevity Lifehacks is where I put my notes, thoughts, and solutions that are based on new research in the fields of healthspan and longevity. After 3+ years, it’s become hard for me to keep track of everything - how the interventions tie together, what is likely to be important for me to actually act on right now, and what I need to come back to at a later stage of life. So I’m putting together a series of hubs that tie together the articles on Longevity Lifehacks. I’m also workin
Fibronectin, blood-brain barrier, and brain health (opens the original)
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For several decades, Alzheimer’s research has focused on preventing the buildup of amyloid-beta plaque in the brain. Amyloid beta is a peptide fragment of a larger glycoprotein called the amyloid precursor protein (APP), which is involved in basic synaptic regulation and neuroprotection. While amyloid-beta plaque clearly plays some kind of role in the pathogenesis of Alzheimer’s disease, the drugs developed to block amyloid-beta formation haven’t helped much with Alzheimer’s symptoms. At best, t
Research Roundup: Gut metabolite reduces age-related inflammation | GLP-1 RAs for Aging (opens the original)
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A geroprotective probiotic and its functional metabolite counteract inflammaging to extend healthspan (Nature Aging, Aug. 2026)Researchers in China analyzed multi-omics data from multiple Chinese cohorts to map age-related changes in the gut microbiome and metabolites. They found that B. pseudocatenulatum levels decrease with older age consistently across the cohorts. And that the Bifido metabolite, 5-AVAB, declined physiologically in older humans. Switching to old mice, the researchers found t
Semaglutide and lung fibrosis (opens the original)
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Semaglutide is a GLP-1 receptor agonist, sold under the brand names Ozempic (diabetes) and Wegovy (weight loss). It’s also available through weight loss websites as a compounded pharmacy option, usually combined with B vitamins, and through peptide shops. While best known for its role in insulin signaling and signaling for fullness, GLP1 is a peptide hormone that acts on receptors throughout the body - including in the heart, vasculature, mast cells, and even the lungs.A new study this week look
Imidazole propionate (ImP) and dementia (opens the original)
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Imidazole propionate (ImP) is a metabolite formed when certain types of gut microbes break down the amino acid histidine. A new study in Nature Communications shows that ImP plays a role in Alzheimer’s pathology. This gut metabolite in humans is associated with lower cognitive scores prior to dementia diagnosis, and in mice, researchers were able to show that it has a causal role in Alzheimer’s disease. I’m going to go through the study, and then pull in a couple of ways to reduce ImP levels and
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