Hormone Insight
Discuss Diabetes and Endocrinology studies in a simplified manner. Expand your knowledge in Diabetes and Endocrinology.
- Indexed episodes, last 90 days
- 2
- Latest publication
- Sep 11, 2026
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- Checking…
- Earliest in this view
- Aug 22, 2026
Latest episodes
CATALYST: Mifepristone, HbA1c and Treatment Burden -- Clinical Evidence for Doctors (opens the original)
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An HbA1c benefit is only one part of a clinical decision. This Hormone Insight evidence review examines the randomized treatment phase of CATALYST: mifepristone in selected adults with difficult-to-control type 2 diabetes and biochemical hypercortisolism. We review the population and trial design, the 24-week HbA1c and weight results, and findings on blood pressure, hypokalaemia, treatment discontinuation and serious adverse events. We also discuss missing data, secondary-endpoint multiplicity a
SOUL: Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes (opens the original)
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SOUL is a large randomized trial of oral semaglutide in adults with type 2 diabetes and established cardiovascular or kidney disease. In this Hormone Insight clinical evidence discussion, we cover the five-part PICO, the primary MACE result, absolute event rates, the non-significant kidney secondary outcome, patient selection, and limits of generalization. Fahad narration, clean voice-only production, no music. Primary source: PMID 40162642. DOI 10.1056/NEJMoa2501006. For healthcare professional
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