HeyJaredGround Truths
Facts, data, and analytics about biomedical matters. erictopol.substack.com
- Indexed episodes, last 90 days
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Marios Georgakis: Why Did Two Major Clinical Trials for Heart Disease Fail? (opens the original)
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In recent weeks the results (announced by press release) of 2 major placebo-controlled randomized trials—ZEUS, testing an interleukin-6 (IL-6) blocker vs inflammation, and HORIZON, testing a drug to lower Lp(a), indicated failure to achieve their primary endpoint. Are we maxxed out for new treatments vs heart disease, as this article in the WSJ (←gift link) today asserts? “Cardiovascular drug development is starting to look a bit like the modern oil industry. The easy wells have been tapped. Wha
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