HeyJaredFertility and Hormones | Dr. Huang
Dr. Huang shares questions from patients, residents, fellows, staff, and medical students regarding infertility, infertility treatment and hormones.
- Indexed issues, last 90 days
- 12
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- Sep 28, 2026
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- Jul 13, 2026
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Case #47 “I had regular periods before. Many of my teammates still have them. Why is that?” asked Ms. Nichols, who developed amenorrhea after training for a marathon. (opens the original)
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Ms. Nichols, 32 years old, G1P1001, came to clinic for secondary amenorrhea and a desire to have a second child. She conceived naturally three years ago and had a normal delivery. She has run marathons since college. She resumed running soon after delivery. Normally, she and her teammates run 40 miles a week. Blood tests showed normal thyroid function, normal prolactin, an estradiol of 30 pg/mL, FSH at 3 mIU/ml and LH below the detection limit. Transvaginal ultrasound showed normal uterus, 3 mm
An injection‑lite approach to IVF patients with TRYPANOPHOBIA (fear of needles): Elonva® (opens the original)
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Daily injections—often involving multiple medications at separate sites—are widely accepted by IVF patients as the norm during ovarian stimulation. For potential patients dealing with needle anxiety or clinical trypanophobia (an intense fear of needles), this step can be incredibly daunting and difficult to accept.Thanks to advancements in molecular biology, a recombinant FSH with a long half-life is available. One example is Elonva®, a long-acting corifollitropin alfa available across the EU (b
Oxytocin receptor antagonist, endometriosis pain and embryo transfer (opens the original)
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A recent research letter (Fertility and Sterility, 2025; 126, 177-179) showed IV infusion of Atosiban (an oxytocin receptor antagonist) during menstrual days significantly relieved endometriosis-related pain. This is a phase II trial on 11 patients (four had adenomyosis). The severity of pain during the course of treatment was rated using a numeric rating scale. Despite small number of observations and preliminary results, it is intriguing. I decided to dig deeper.Oxytocin (OT)Oxytocin is a nine
Progestin-primed ovarian stimulation (PPOS) -- “Poor man’s short GnRH agonist protocol” (opens the original)
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The lowest cost of Ganirelix for a cash paying patient is about $200 a piece with the help of GoodRx coupon. In addition to hMG and trigger medication, a typical GnRH antagonist cycle costs an additional $1,000, based on the average range of 4 to 6 doses per cycle. This represents about 25% of the total medication cost.A novel IVF ovarian stimulation protocol using medroxyprogesterone (Provera) to inhibit the premature LH surge was first published in 2015 — progestin-primed ovarian stimulation (
Case #46 “How could this happen? Is there a solution?” asked Ms. Miller. None of her ten eggs that received ICSI was fertilized. (opens the original)
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Ms. Miller, 42 years old and healthy, came to clinic with her husband to review her recent IVF+ICSI cycle. She used antagonist protocol and dual trigger (0.5 mg Lupron and 3,300 units hCG). On the day of trigger (11th days of stimulation), the parameters were: lead follicle 22 mm (1), 19 mm (2), 18 mm (2), 17 mm (3), 16 mm (2), 15 mm (1), 14 mm (2), and… Read more
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