HeyJaredEndgame with Amanda Cassatt
The world is changing at an accelerating pace—Endgame is here to make sense of it. Hosted by Amanda Cassatt, founder of Serotonin, this podcast brings you conversations with the visionaries driving breakthrough technologies and shaping the future.
- Indexed episodes, last 90 days
- 8
- Latest publication
- Sep 9, 2026
- Audience
- Checking…
- Earliest in this view
- Jul 9, 2026
Latest episodes
Are Humans Being Replaced? The Truth About AI | Malcolm & Simone Collins (opens the original)
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Malcolm and Simone Collins became known as prominent voices in the pronatalist movement. But today, much of their work is focused on a different question: what happens to humans, culture, education, and future generations as artificial intelligence transforms society? In this episode of Endgame, Amanda Cassatt sits down with Malcolm and Simone to explore how AI is reshaping internet culture, why they believe the next major culture war is forming around artificial intelligence, and what it means
Who Wins the 2027 Crypto Bull Market | Santiago R. Santos, Inversion (opens the original)
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Santiago R. Santos of Inversion was investing in DeFi before “DeFi” was even a widely used term. As a former partner at ParaFi and an early investor in projects including Aave, Arbitrum, and Polymarket, he watched Ethereum evolve from an experimental smart contract platform into the foundation of a massive onchain economy. But the growth of crypto has also changed his investment thesis. In this episode of Endgame, Amanda Cassatt and Santiago R. Santos examine whether Ethereum can succeed while E
The Worst Outcome Is a High IQ Psychopath | Jonathan Anomaly (opens the original)
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What if we could select the optimal genetic traits for our children? In this episode of Endgame, Amanda Cassatt sits down with bioethicist and philosopher Jonathan Anomaly to explore the cutting edge of reproductive biotechnology. They dismantle the social and political taboos surrounding genetic curation, tracing everything from the uncomfortable reality of cognitive capacities and human success to the macro ethical implications of advanced embryo selection. Jonathan argues why denying genetic
The Man Who Built the Metaverse Explains Why Meta Failed | Philip Rosedale (opens the original)
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Corporate metaverses failed the moment big tech tried to turn human connection into a closed retail space. In this episode of Endgame, Second Life creator Philip Rosedale joins Amanda Cassatt to explain why corporate giants spent $80 billion and still couldn't build a functional virtual world. Moving far beyond the surface-level hype of Silicon Valley, Philip exposes how algorithmic feeds and centralized interfaces are stripping away genuine human sovereignty, leaving us with a cheap illusion of
Sui's Kostas Chalkias: I Told Them to Freeze the $163 Million (opens the original)
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As chief cryptographer of Sui and Mysten Labs, Kostas Chalkias helped design a blockchain built on more than 100 published cryptography papers and an object-based architecture fast enough to let AI agents chain dozens of transactions into a single intent, without skipping the security research most "fast chains" leave out entirely. In this episode of Endgame, Amanda Cassatt sits down with Kostas to break down why validators froze $163 million after the Cetus hack, why post-quantum migration can'
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