HeyJaredDr RR Baliga's "Got Knowledge Doc" Podkast
"Got Knowledge Doc" Podkast with Dr. RR BaligaThe "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation.
- Indexed episodes, last 90 days
- 79
- Latest publication
- Sep 20, 2026
- Audience
- Checking…
- Earliest in this view
- Jul 4, 2026
Latest episodes
🧬 One Mutation, Massive Risk: EGFR T790M and Inherited Lung Cancer (opens the original)
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🧬 Rare Variant, Real Risk: EGFR T790M and Lung Cancer Can lung cancer risk be inherited—even in never-smokers? 🫁🚭 In >3.3 million individuals, germline EGFR T790M was rare (~1 in 15,850) but strongly associated with lung cancer ( OR 25.18 ). The association was particularly striking among never-smokers, and the variant showed remarkable lung-cancer specificity. A Southern Appalachian founder effect also revealed how genes, geography & history can converge on modern disease risk. 🗺️🧬 💡 A compelli
🌱 A Probiotic for Longevity? Microbes, Metabolites & Healthier Aging (opens the original)
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🦠 Could a gut microbe help counter inflammaging? A fascinating Nature Aging study identifies Bifidobacterium pseudocatenulatum as a candidate geroprotective species that declines with age. Its metabolite 5-AVAB also falls with aging. In naturally aged mice, probiotic treatment improved intestinal homeostasis, reduced multiorgan inflammaging, enhanced cognitive–motor performance, and extended healthspan; 5-AVAB reproduced several benefits. 🧠💪 🎯 Microbiome → metabolite → inflammaging → healthspan.
🌾 60–100 Grams a Day: The Whole-Grain Cardiometabolic Advantage (opens the original)
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🌾 Whole Grains, Real Gains! 🫀 How much whole grain does it take to move cardiometabolic risk factors? A meta-analysis of 87 randomized trials suggests a sweet spot around 60–100 g/day dry weight . Benefits were most clinically relevant for lipids and systolic blood pressure , while effects on several other risk factors were modest. 📉 💡 The lesson: cardiovascular prevention may come not from one dramatic dietary effect, but from multiple small gains working together . 🎙️ Dr RR Baliga's Podkast fo
🫀 The Heart's Forgotten Drain: Aging, Lymphatics & Inflammation (opens the original)
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🫀 Could the aging heart have a drainage problem? A fascinating study in Nature Cardiovascular Research shows that aging reduces cardiac lymphatic vessels, with tighter junctions, impaired clearance, inflammation, edema, fibrinogen and amyloid accumulation. 🔥 🧬 Mechanistically: aging → ↓VEGFC → ↑nuclear IL-33 → lymphatic endothelial cell loss/remodeling. 🎯 IL-33 silencing or VEGFC restoration rescued lymphatic density and reduced inflammation—but VEGFC did not reverse established diastolic dysfun
🩸 Reengineering Coagulation: Bridging Factors, Bypassing Factor VIII, Transforming Hemophilia (opens the original)
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🩸 Can you replace factor VIII without actually replacing factor VIII? Emicizumab does something more ingenious: this bispecific antibody bridges factor IXa and factor X, functionally recreating a critical role of factor VIIIa. 🔬 After screening ~40,000 candidates, researchers engineered a therapy that enables convenient subcutaneous prophylaxis and works with or without factor VIII inhibitors. 💉 🏆 Recognized with the 2026 Lasker–DeBakey Clinical Medical Research Award , it offers a powerful less
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