Diabetes Trial Files
Free bimonthly newsletter that summarizes the most significant, practice-changing diabetes randomized controlled trials, straight to your inbox.
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Diabetes Trial Files: Orforglipron vs. Dapa, CagriSema Add-On, and Retatrutide in T2DM (opens the original)
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Orforglipron compared with dapagliflozin in adults with type 2 diabetes and inadequate glycaemic control with metformin (ACHIEVE-2)Welch M et al. The Lancet (July 2026)Bottom Line: This phase 3, multicentre, open-label clinical trial evaluated the efficacy and safety of orforglipron (3 mg, 12 mg, or 36 mg) versus dapagliflozin (10 mg) in adults with type 2 diabetes inadequately controlled by metformin over 40 weeks. A total of 962 participants were randomized, with the primary outcome being the
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