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Decoding Longevity

A podcast dedicated to unraveling the mysteries of aging through the lens of cutting-edge science. Each episode breaks down the latest research papers in the field of geroscience, offering clear, insightful discussions on longevity, biological aging, and the quest for…

Podcast · By Raghav Sehgal · English · Official site

Indexed episodes, last 90 days
5
Latest publication
Sep 16, 2026
Audience
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Earliest in this view
Jul 22, 2026

Latest episodes

  1. Episode · Sep 16, 2026

    Is Rapamycin Dead? — A Conversation with Matt Kaeberlein (opens the original)

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    What if we could slow biological aging itself—not just treat the diseases that come with it? In Episode 34 of Decoding Longevity , Raghav Sehgal and Dr. Macsue Jacques sit down with Professor Matt Kaeberlein to explore the biology of aging and what it might mean to actually intervene in the aging process. They discuss mTOR and rapamycin, the debate around rapamycin in humans, and why Matt believes some recent evidence has been misunderstood. The conversation also covers the Dog Aging Project, th

  2. Episode · Sep 4, 2026

    Can a Shingles Vaccine Slow Down Dementia? Survival, Cognitive Preservation, and Immune Modulation (opens the original)

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    Could a shingles vaccine also influence dementia? In Episode 33 of Decoding Longevity, Dr. Raghav Sehgal and Dr. Macsue Jacques are joined by Dr. Moshe Shay Ben-Haim to explore his team’s findings linking the Shingrix vaccine with improved survival and cognitive preservation in people living with dementia. They discuss trained immunity, latent viruses, epigenetics, and what this surprising connection could mean for the future of neurodegeneration and longevity research. Importantly, the findings

  3. Episode · Aug 19, 2026

    Inflammation, Organ Age & Longevity - A Conversation with David Furman (opens the original)

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    What if your immune system is one of the engines driving aging? In this episode, David Furman explores the biology of immune aging, chronic inflammation, inflammatory age, organ-specific aging, and intrinsic capacity—and how biomarkers could help us measure and ultimately change the trajectory of aging. A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors: https://pubmed.ncbi.nlm.nih.gov/40467932/

  4. Episode · Aug 5, 2026

    Moving Beyond Mortality Clocks: Responsive Rate of Aging Biomarkers with Associate Professor Dan Belsky (opens the original)

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    Can two people of the same age be aging at completely different speeds? In this episode, Dr. Raghav Sehgal and Dr. Macsue Jacques speak with Associate Professor Daniel W. Belsky about the science behind DunedinPACE and why measuring the pace of aging may be more valuable than estimating biological age. The conversation covers the Dunedin Study, aging biomarkers, the CALERIE trial, and the ARPA-H FAST Initiative—offering a look at how researchers are building the next generation of tools to evalu

  5. Episode · Jul 22, 2026

    Testing the Longevity Promise: What Mice Can Really Teach Us About Slowing Ageing — A Conversation with Professor Richard Miller (opens the original)

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    Can we really slow biological aging? In this episode of Decoding Longevity , Professor Richard A. Miller—Professor of Pathology at the University of Michigan and a founding leader of the National Institute on Aging's Interventions Testing Program (ITP) —joins us to explore how scientists determine whether a longevity intervention truly works. From rapamycin and acarbose to biomarkers, healthspan, and the challenges of translating mouse studies into human medicine, this conversation examines what

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