HeyJaredDarwin's Spectre
Evolutionary biology, its history, its latest discoveries, and - most importantly - its relevance for health, aging, well being, and understanding everyday life as a human being.
- Indexed issues, last 90 days
- 17
- Latest publication
- Sep 30, 2026
- Audience
- Checking…
- Earliest in this view
- Aug 23, 2026
Latest issues
How AI Makes Sense of Genomes (opens the original)
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This is the best AI-generated explanation of what the futures of biology and medicine look like, once we escape from the death-grip of reductionism. The AI discussants do a much better job than I can, because they don’t suffer from the curse of too much knowledge. See, even mediocrity has its time and place ;-) Read more
What I Like About AI (opens the original)
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There are few issues as portentous in our time as AI, misleadingly short for Artificial Intelligence. [I think of it as Artificial and Perseverant Mediocrity.] Almost every literate person connected to the internet has tried it. Some have even enjoyed it.Confession: I use AI to “Full Self-Drive (supervised)” a Tesla Model 3. It’s mediocre, but usually reliable. After almost forty years in Southern California, I am sick of all the time I spend driving a car. So FSD reduces my daily driving burden
The Death of the Longevity Genes (opens the original)
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This week we are going even deeper on how we will make progress with aging in the genomic era. This introductory video starts with the first evidence, way back from 2010, that healthspan needs to be enhanced through the use of networks of numerous re-tuned bits of physiology. Subscribe now
The Immediate Evolutionary Ray Gun (opens the original)
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It’s all about re-tuning, not repairing. The first re-tuning of adaptation to counter aging is to minimize mismatch. But how you minimize mismatch depends on age and ancestry. Read more
This Healthspan Century (opens the original)
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<img alt="" class="sizing-normal" height="813" src="https://substackcdn.com/image/fetch/$s_!uJSf!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F41f727a3-8f03-4a79-96f8-45a7733e3e99_2752x1536.pn
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