CCCritical Care Perspectives in Emergency Medicine

1. Episode · Sep 1, 2026

   How Much Oxygen Should Post-Arrest Patients Receive? (opens the original)

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   Brain damage and death from ischemic encephalopathy is common after cardiac arrest. Animal studies and limited observational studies suggest that high oxygen exposure after ROSC may result in neuronal death. As such, it is hypothesized that limiting oxygen exposure (conservative oxygen) many attenuate reperfusion injury and improve outcomes. At present, analyses from 2 trials in patients with cardiac arrest in the ICU suggested a benefit with conservative oxygen therapy. In contrast, a trial of

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2. Episode · Jul 27, 2026

   Fluids or Early Pressors for Septic Shock? (opens the original)

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   The optimal approach to IVF administration and timing of vasopressor initiation for patients in septic shock remains uncertain. International sepsis guidelines currently provide a weak recommendation on IVF administration within the first three hours of patients with sepsis-induced hypotension, but do not make any specific recommendations on the timing of vasopressor initiation. The largest and most recent randomized trial to compare a restrictive fluid strategy with early vasopressor initiation

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