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Compounding Leadership

25+ years of Life Sciences boardroom experience distilled into practical Leadership playbooks. No fluff. No corporate speak. Just the hard truths that actually move the needle.

Newsletter · By Nick Makris · Official site

Indexed issues, last 90 days
7
Latest publication
Sep 27, 2026
Audience
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Earliest in this view
Jul 14, 2026

Latest issues

  1. Issue · Sep 27, 2026

    How Target Lost $2 Billion in Canada in 24 Months (opens the original)

    Excerpt · Critical tone

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    In January 2011, Target committed $1.8 billion to acquire Zellers leases across Canada. Canadians were cheering. Less than two years after opening its first stores, it was gone: 133 stores closed, 17,600 people laid off, nearly $2 billion in operating losses, and a $5.1 billion exit charge.In this episode, I walk through the real operational breakdown behind Target Canada. It wasn’t pricing, and it wasn’t competition. It was what happens when an organization scales an uncalibrated machine before

  2. Issue · Sep 22, 2026

    The Mistakes That Leave No Paper Trail (opens the original)

    Excerpt · Critical tone

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    The most expensive decision in your business isn't the one you got wrong. It's the one you keep waiting to make. Here is what I learned about the hidden price of playing it safe, and why the most expensive mistakes leave no paper trail.<source type="ima

  3. Issue · Sep 8, 2026

    The Oatmeal Cookie That Outlasted Every Strategy (opens the original)

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    ❇️ Every company I have ever worked for had ONE thing in common. And it wasn't the mission statement, the strategy, or the CEO. It was that Oatmeal Cookie 🍪.<img alt="" class="sizing-normal" height="1216" src="https://s

  4. Issue · Aug 25, 2026

    Why Leaders Need Boredom (opens the original)

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    <img alt="brown wooden seat beside white wall" class="sizing-normal" height="680.1151566469094" src="https://images.unsplash.com/photo-1629867218251-92a5eb8cd7aa?crop=entropy&cs=tinysrgb&fit=max&fm=jpg&ixid=M3wzMDAzMzh8MHwxfH

  5. Issue · Aug 11, 2026

    Stop Swinging at Every Pitch. (opens the original)

    Excerpt · Neutral tone

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    ❇️ Most leaders are exhausted because they feel they must swing at every email, competitor move, and market ripple. But in the high-stakes game of leadership, there are no "called strikes." The goal is not to be busy: it is to be ready when the one pitch you are uniquely equipped to win enters your sweet spot.<a class="image-link image2 is-viewable-img" href="https://images.unsplash.com/photo-1591270728038-3e9b4a619b0d?crop=entropy&cs=tinysrgb&fit=max&fm=jpg&ixid=M3wzMDAzMzh8MHwxfHNlYXJjaHwxMTZ8

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