Clinical Pharmacology Podcast with Nathan Teuscher
I discuss clinical pharmacology and pharmacometrics topics from the perspective of drug development scientists.
- Indexed episodes, last 90 days
- 2
- Latest publication
- Aug 24, 2026
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- Earliest in this view
- Jul 27, 2026
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Renal and Hepatic Impairment (Ep. 59) (opens the original)
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Today’s episode is a discussion of renal and hepatic impairment. I review the biology of the kidney and liver and how we analyze pharmacokinetic data to assess their impact on drug exposure. Links discussed in the show: You can connect with me on LinkedIn and send me a message Send me a message Sign up for my newsletter Copyright Teuscher Solutions LLC All Rights Reserved
Beyond Small Molecules—Allometric Scaling for Biologics and Engineered mAbs (Ep. 58) (opens the original)
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Today’s episode is about allometric scaling with therapeutic antibodies. I discuss differences from small molecules, how to handle antibodies with engineered Fc regions (e.g. YTE or LS), and using allometry to extrapolate from adults to pediatrics for these antibodies. Links discussed in the show: Haray and Tachibana’s article on allometric exponents for monoclonal antibodies Exponents for standard antibodies: CL = 0.8, Q = 0.75, Vc = 1/.0, Vp = 0.95 Exponents for modified antibodies: CL = 0.55,
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