Clin Gastroenterol Hepatol
- Indexed articles, last 90 days
- 10
- Latest publication
- Sep 28, 2026
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- Aug 26, 2026
Latest articles
Corticosteroids Linked to Serious Infections in IBD (opens the original)
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A large Swedish registry study of patients with inflammatory bowel disease (IBD) found that adding corticosteroids to any baseline therapy was associated with two- to fourfold higher risk for serious infections, with risk climbing alongside cumulative steroid dose. The relative risk increase was steepest in children; however, older adults still bore the highest absolute infection burden. "Our findings address important knowledge gaps regarding the real-world safety profiles of immunosuppressive
Serum Protein Can Flag Complicated CD Years Before Diagnosis (opens the original)
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High serum regenerating islet-derived 3-alpha (REG3-alpha) levels were associated with an increased risk for Crohn's disease (CD) progression and complicated CD — even in patients with mild or inactive disease and up to 10 years before diagnosis. Notably, REG3-alpha flagged this risk independently of standard tests such as C-reactive protein (CRP) and endoscopy. "Taken together, [the] findings suggest that REG3-alpha may serve not only as a dynamic inflammatory biomarker, but also as a tool for
Americans Pop Probiotics but Skip the Fiber, Experts Warn (opens the original)
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The use of probiotic supplements increased sharply in the US from 2009 to 2023 — by 287% among individuals aged 20 years or older and 786% among individuals younger than 20 years — whereas the consumption of microbiome-supportive foods remained practically unchanged. Even though probiotic users consumed greater amounts of fiber and more foods with high microbial content than nonusers, this dietary advantage appeared to fade over time. "The increasing probiotic supplement use by adults and childr
New AGA Guidance on Cancer Surveillance in Seniors (opens the original)
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The American Gastroenterological Association (AGA) has released updated clinical practice guidance on the surveillance of metaplastic and premalignant conditions of the esophagus and colorectum in older adults. Published in Clinical Gastroenterology and Hepatology, the expert review and practice update provides a brief synthesis of existing literature and frames studies to foster nuanced decision making on surveillance cessation in older adults. “The US population is aging, and with the numerous
MRCP Detects PSC in 10% of New IBD Cases (opens the original)
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Radiological primary sclerosing cholangitis (PSC) or PSC-like lesions were detected in nearly 1 in 10 patients with newly diagnosed inflammatory bowel disease (IBD) in a prospective Danish cohort study. Nearly half of those with PSC had normal liver biochemistry at diagnosis. "This study highlights that MRCP may represent a potential diagnostic tool at IBD onset to improve early detection and disease management in PSC-IBD. However, long-term clinical implications remain uncertain, and prospectiv
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