HeyJaredBrain Ponderings podcast with Dr. Mark Mattson
Conversations with neuroscientists, neurologists, evolutionary biologists, anthropologists, computer scientists, and others that ponder the brain.
- Indexed episodes, last 90 days
- 11
- Latest publication
- Sep 15, 2026
- Audience
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- Earliest in this view
- Jul 7, 2026
Latest episodes
Toren Finkel: Mitohormesis, the Integrated Stress Response, Lysosomes and mTOR in Aging and Disease (opens the original)
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Cells have evolved elaborate and highly-coordinated ways of responding to the stresses they encounter in the course of their normal functions and in response to environmental challenges. Research is revealing the that mitochondria are a hub of adaptive cellular stress responses. Mitochondria sense oxidative, metabolic, and ionic stress and then triggers an integrated adaptive stress response. In this episode I talk with University of Pittsburgh professor Toren Finkel about his career with a focu
Kiran Thakur: Vaccine-Preventable Viral and Bacterial Neurological Disease Mechanisms and Management (opens the original)
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Measles, Polio, COVID, AIDS, tick-borne encephalitis, Lyme disease, meningitis, yellow fever, and Ebola are examples of diseases that can be fatal and those who survive the infection may have long-term neurological disability resulting from damage to neural circuits caused by the virus or bacteria. Effective vaccines have been developed for all of these infectious diseases except AIDS for which vaccines against HIV are being developed. In this episode I talk with Dr. Kiran Thakur, Director of th
Stuart Lipton: Excitotoxicity, Nitric Oxide, Protein Nitrosylation, Air Pollution, and Alzheimer's (opens the original)
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Protein nitrosylation a process by which redox reactions of nitric oxide (NO) and proteins result in covalent modification of the sulfur in the amino acid cysteine resulting in S-nitrosothiol (SNO). In this episode I talk with Scripps Research Professor Stuart Lipton about his research career highlighting the discovery that protein nitrosylation occurs on numerous proteins in neurons and contributes to the dysfunction and degeneration of neurons in Alzheimer's disease and other neurodegenerative
Boushra Dalile: SCFAs Produced by Gut Bacteria Affect Stress Responses and Cognition in Humans (opens the original)
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Understanding how diet influences brain health is a very important area of research. During the past two decades there has been an exponential increase in research on the gut microbiome and its roles in health and disease. Diets high in fiber are not only improve gut health but may also be beneficial for other organ systems including the brain. Gut bacteria ferment dietary fibers resulting in the production of the short-chain fatty acids (SCFAs) butyrate, propionate, and acetate. In this episode
Eric Klann: Activity-Dependent Protein Synthesis: Roles in Memory, and Neurological Disorders (opens the original)
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The molecular machinery that translates the messenger RNAs into protein is located in ribosomes. Ribosomes are present within neurons in or near synapses, where they are particularly abundant in postsynaptic sites. Evidence suggests that local protein synthesis is required for the 'strengthening' (increased size and responsivity) of synapses that is believed to be and essential process in the encoding of memories. However, there are many different proteins that regulate protein synthesis and onl
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