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All Things Tox

Exploring the interplay of fundamental physical principles with biological systems: genetics, biochemistry, pharmacology, physiology, pathology, toxicology, chemical carcinogenesis, and some legal implications. (energy, mass, space, and time)

Newsletter · By Brian H Mathison PhD · English · Official site

Indexed issues, last 90 days
8
Latest publication
Sep 16, 2026
Audience
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Earliest in this view
Jul 8, 2026

Latest issues

  1. Issue · Sep 16, 2026

    AI is Alive! (opens the original)

    Excerpt · Neutral tone

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    A recent essay in Noema “A New Form of Life” made the case that AI running in data centers is a new form of life! 1 —- Not in a metaphorical sense, but literally. <source type="i

  2. Issue · Sep 11, 2026

    Hazard Is Not Risk (opens the original)

    Excerpt · Critical tone

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    We’ve seen this movie before in toxicology. I’ve seen the recent news. I’ve seen the Hollywood script. Something is Possible!<img alt="" class="sizing-normal" height="986" src="https://substackcdn

  3. Issue · Aug 5, 2026

    Why I'm Here (opens the original)

    Excerpt · Positive tone

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    The longer I have studied toxicology, the less interested I have become in certainty and the more interested I have become in understanding. I spent some time reflecting on my discourse and those reflections guided the creation of this graphic. <img alt="" class="si

  4. Issue · Jul 28, 2026

    Enzymatic and Non-Enzymatic Browning (opens the original)

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    Browning, enzymatic and non-enzymatic, has generated thousands of papers on food quality and toxicology. Food waste and spoilage sit at the center, polyphenol oxidase gets most of the attention, although it’s not the whole story. PPO oxidizes phenolic compounds to o-quinones when oxygen is present. Those quinones are unstable and reactive and polymerize into the brown pigments we actually see. It is all chemistry running predictably. It’s not all bad. Black tea, coffee, and cocoa owe their chara

  5. Issue · Jul 26, 2026

    I’m a “PhD-Type” (opens the original)

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    While I’m not a fan of Rhonda Patrick (FoundMyFitness), her messaging, her style, or her influencer persona. Her latest smoothie-bananas commentary seems to have triggered a new round of banana-induced hysteria. But responses have been far worse than the original claim.<

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