HeyJaredAging-US
Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases.
- Indexed episodes, last 90 days
- 34
- Latest publication
- Sep 21, 2026
- Audience
- Checking…
- Earliest in this view
- Jul 6, 2026
Latest episodes
The “Guardian Paradox” Links Chronic DNA Damage Response to Aging (opens the original)
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BUFFALO, NY — September 21, 2026 — A new #review was #published in Volume 18 of Aging on August 31, 2026, titled “The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.” The review presents a new framework proposing that chronic overactivation of the DNA damage response (DDR) may serve as a major integrating driver of biological aging. Rather than framing aging in the same mutation-centered terms often applied
EDITORS’ CHOICE: Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging (opens the original)
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A research paper recently published in Aging, titled “Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging,” investigated how a human-relevant mutation in the PTPN6 gene, which encodes the immune and metabolic regulator SHP-1, affects immune and liver function during aging. Using mice carrying the mutation, the researchers found that older mutant mice had improved glucose tolerance and hepatic insulin sensitivity, but also developed liver abnormalities characterized by
Human-Relevant Ptpn6 Mutation Reveals Complex Links Between Immunity, Metabolism and Liver Aging (opens the original)
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BUFFALO, NY — September 16, 2026 — A new #research paper was #published in Volume 18 of Aging on August 28, 2026, titled “Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging.” The study examines how a mutation affecting the immune and metabolic regulator SHP-1 reshapes liver function during aging, revealing that improved glucose metabolism can coexist with immune-cell accumulation and liver fibrosis. The research was led by first author Beisy Laborit Labrada from the I
Evidence for Cellular Senescence as a Driver of Aging Stronger Than for Somatic Mutations (opens the original)
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BUFFALO, NY — September 14, 2026 — A new #review was #published in Volume 18 of Aging on August 26, 2026, titled “Assessing mechanisms and evidence of a causal role for cellular senescence and somatic mutations in aging.” The review examines two biological processes strongly associated with aging—cellular senescence and somatic DNA mutations—and evaluates whether the evidence supports their causal contribution to age-related functional decline. The review was authored by Lucrezia A. Trastus and
Misha Blagosklonny’s Ideas Reshaped Thinking About Aging (opens the original)
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Scientific progress often begins with questioning assumptions that have shaped a field for decades. Few researchers embodied this approach as strongly as Dr. Mikhail “Misha” Blagosklonny, an oncologist and biogerontologist whose unconventional theories challenged traditional explanations of why organisms age. An essay published in Volume 18 of Aging titled “Misha Blagosklonny: a life of ideas,” reflects on Dr. Blagosklonny’s life, scientific career, and contributions to the biology of aging. Ful
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